desvenlafaxine will raise the amount or impact of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, four hundred mg) lessen the CYP2D6 substrate dose by approximately 50%; no dosage adjustment needed with desvenlafaxine doses seven consecutive days immediately previous to taking alvimopan).
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Stay away from use when getting any oral drug that may be dependent on threshold concentrations for efficacy. Interactions listed are consultant illustrations and don't contain all feasible clinical examples.
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